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KMID : 1140420190280010018
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Journal of Obesity & Metabolic Syndrome
2019 Volume.28 No. 1 p.18 ~ p.29
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The Effects of Hypoglycemic Agents on Non-alcoholic Fatty Liver Disease: Focused on Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists
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Jung Chan-Hee
Mok Ji-Oh
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Abstract
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The only known, effective intervention for non-alcoholic fatty liver disease (NAFLD) is weight loss, and there is no approved pharmacotherapy. Recently, new hypoglycemic agents, such as sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs), and their effects on NAFLD have received substantial interest. Herein, we review the currently available human studies regarding the effects of SGLT2 inhibitors and GLP-1RAs on NAFLD/non-alcoholic steatohepatitis in patients with type 2 diabetes mellitus, and we describe the possible mechanisms explaining the positive effects of these agents on NAFLD.
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KEYWORD
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Sodium-glucose cotransporter 2 inhibitor, Glucagon-like peptide-1 receptor agonist, Non-alcoholic fatty liver disease, Type 2 diabetes mellitus
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